The "Paris Institute for Transplantation & Organ Regeneration" (PITOR)

Is focused on the field of transplantation and organ regeneration. Its goal is to bring together research in transplantation and regenerative medicine within the University of Paris Cité, primarily leveraging data sciences and artificial intelligence. The Institute aims to strengthen collaborations and training between research teams and clinical teams from all medical and surgical specialties to promote interdisciplinarity and undertake ambitious projects. This institute brings together teams and transplant specialists from all over France, and the Paris Transplant Group team is actively involved in the development of PITOR.

Transplantation: A Global Health Challenge

At present, transplantation is the most effective treatment for end-stage organ failures affecting millions of individuals worldwide. This number continues to rise due to the aging population and the increasing incidence of cardiovascular and metabolic diseases.

However, only 25% of patients awaiting transplants are actually transplanted each year in France. Transplantation, which is both restricted and costly, has a significant economic impact on healthcare systems globally.

This situation has led many research teams in solid organ transplantation in Paris and its region to work on these issues.

The PITOR Institute aims to connect these experts by bringing together representatives from various medical and surgical specialties involved in the transplantation process. The goal is to enhance fundamental, translational, and clinical research to improve the care of transplant patients and grafts.

At the national level, the « Ministerial Plan for Organ and Tissue Donation and Transplantation 2022-2026 » aims to revitalize the organ transplantation sector. The « Paris Institute for Transplantation & Organ Regeneration, » an external institute, aligns with many of these objectives.

Pursuing Innovation and Multidisciplinarity

Through a comprehensive approach to transplantation and a focus on improving the patient’s transplant journey and graft outcomes, the Institute allows numerous research units within the University of Paris Cité perimeter and in collaboration with INSERM, CNRS, and Institut Pasteur, as well as institutions outside University of Paris Cité such as the University of Paris Saclay and Sorbonne University, to pool their resources.

Sharing Knowledge and Advancements

With a commitment to knowledge transfer, the Institute contributes to the structuring and unification of education in regenerative medicine within the faculties of Health and Sciences at the University of Paris Cité. Pedagogical and technological innovations will be implemented to enhance the quality and accessibility of Institute’s education through partnerships with digital platforms.

To learn more about the work carried out by the PITOR Institute and stay updated on medical advancements, the Institute will disseminate scientific progress to a wide audience, from the scientific community to patients and citizens, through dedicated events.

Research Focus

The Institute’s research activities are structured around four key axes:

  • Understanding and Treating
  • Diagnosing and Monitoring
  • Optimizing Organ Procurement, Preservation, and Allocation
  • Organoids and Organ-on-a-Chip

These axes are deployed across six thematic areas:

  • Multidimensional Multi-Organ Cohorts
  • Biomarkers and Immunology
  • Organ Procurement, Resuscitation, and Perfusion
  • Tissue Engineering and Precision Medicine
  • Digital Health and Artificial Intelligence
  • Social Sciences and Public Health.